TEM Liquid Flow Brochure | Hummingbird Scientific

Perform in-situ liquid-phase TEM with controlled microfluidic flow, integrated MEMS heating and biasing, and optional dual-inlet reagent mixing for dynamic materials characterization.

Technical Specs

1400 Series

Number of Inlets

1 or 2 depending on model, single outlet

Biasing Contacts

4 on-chip

Tubing Type

User-replaceable microfluidic tubing

Delivery System

Variable speed pressure or flow-controlled liquid delivery system

Tip Type

Removable tip

Flow Type

Continuous flow or static liquid

EELS/EDS Compatible

Yes

Available For:

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Key Features and Capabilities

Reproducible Screw-Free Liquid-Cell Assembly

Achieve reproducible liquid-cell assembly with self-aligning windows and a screw-free sealing design

Removable, Swappable Tip and Tubing

Simplify cleaning with removable and upgradeable holder tips that allow user access for full tubing replacement

Flexible Liquid Cell Operation

Image samples in continuous-flow or static liquid environments using a sealed microfluidic chip assembly

Multimodal Imaging

Correlate electrochemical, heating, and imaging data across TEM, SEM, and X-ray microscopy platforms

Optimized for EELS and EDS

Perform correlative spectroscopy and microscopy for detailed in-situ elemental analysis

Integrated Liquid Heating

Optional add on

Add temperature-controlled liquid-phase TEM capabilities with homogeneous heating, precise temperature regulation, and near-drift-free in-situ imaging

Dual-Flow Liquid Mixing

Optional add on

Accelerate discovery with dual-flow liquid mixing for in-situ liquid phase TEM, capturing dynamic liquid-liquid reactions with greater control and flexibility

Biologic SP-200 Potentiostat

Optional add on

Expand the capabilities of the TEM Liquid Flow Sample Holder with the BioLogic SP-200 potentiostat for quantitative in-situ TEM electrochemistry

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Built for Diverse Applications

Magnetic polarization of nanocrystals within bacterial cells

Bio/Soft Materials

Visualize biological and soft matter systems dynamics, including growth, interactions, and degradation.

Biomineralization

Self-Assembly Processes

Metal-Organic Framework Dynamics

Soft Matter Dynamics

Biomolecular Interactions

Illustration of battery material particles and spectroscopy

Battery Materials

Directly visualize battery cycling, ion transport, dendrite formation, interface evolution, and structural changes.

Charge-Discharge Cycling

Electrochemistry

Study electrodeposition, electrocatalysis, corrosion mechanisms, and electrochemical interface evolution.

Cyclic Voltammetry (CV)

Linear Sweep Voltammetry (LSV)

Chronoamperometry (CA)

Chronopotentiometry (CP)

Electrochemical Impedance (EIS)

Featured Research

Direct imaging of phonon dynamics in self-assembled nanoparticle lattices using liquid-phase TEM

a) Schematics of macroscopic Maxwell lattices and a hinge exhibiting rotational freedom. b) Schematic of a rhombic lattice with structural degeneracy. c) Self-assembly of gold nanocubes into a rhombic Maxwell lattice in via liquid-phase TEM. Time-lapse liquid-phase TEM images overlaid with d) tracked NP centroids and e) the bond network describing the angle at which each rhombus leans. Scale bars, 150 nm. f) Drift-corrected trajectory mapped over a selected region of a stable rhombus lattice. g) Example of the instantaneous displacement of the NPs in one frame. Scale bars, 200 nm.

Reference: Chang Qian, et al. Nature Materials (2025). DOI: 10.1038/s41563-025-02253-3

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Selected Publications

Zahoor Manzoor, R. Karthik, Marcelo Alves Ferreira, Douglas S. Galvao, Nilay Krishna Mukhopadhyay, Thakur Prasad Yadav, Prikshat Dadhwal, Pranith Chander Saka, Cristiano Francisco Woellner, Shamik Chowdhury, Chandra Sekhar Tiwary. “Radio frequency-induced catalysis using multi-component two-dimensional quasicrystals for effective sulfamethoxazole removal from water”. Applied Catalysis B: Environment and Energy (2026)

DOI:

10.1016/j.apcatb.2025.126062

Zahoor Manzoor, Shamik Chowdhury, Guilherme da Silva Lopes Fabris, Bruno Ipaves, Douglas S. Galvão, Chandra Sekhar Tiwary. “Multicomponent 2D quasicrystals as robust photocatalysts for antibiotic degradation: Mechanistic insights via in situ TEM and atomistic simulations”. Journal of Hazardous Materials (2026)

DOI:

10.1016/j.jhazmat.2026.141638

Lau Morten Kaas, Raquel Aymerich-Armengol, Daan Hein Alsem, Christian Danvad Damsgaard, Stig Helveg, Jakob Kibsgaard, Peter Christian Kjærgaard Vesborg. “Liquid thickness estimation in transmission electron microscopy”. Ultramicroscopy (2026)

DOI:

10.1016/j.ultramic.2026.114350

Jonas Hallstrom, Puquan Pan, Jayson Sia, Sangwok Bae, Dingwen Qian, Chang Qian, Sindy Liu, Lehan Yao, Thomas M. Truskett, Delia J. Milliron, Qian Chen, Xiaoming Mao, Paul Bogdan, Nicholas A. Kotov. “Decoding collective dynamics and complexity in nanoparticle assemblies using graph theory”. Science (2026)

DOI:

10.1126/science.aeb5134

Brenna M. Knight, Biao Jin, Yuna Bae, James J. De Yoreo, Patricia M. Dove. “In situ transmission electron microscopy observations of CaCO3 crystallization onto polysaccharide-coated nanoparticles”. CrystEngComm (2026)

DOI:

10.1039/D6CE00012F