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TEM Liquid Flow Sample Holder

Operando heating, biasing under environmental conditions

Technical Specs
1400 Series
Number of Inlets
1 or 2 depending on model, single outlet
Biasing Contacts
4 on-chip
Tubing Type
User-replaceable microfluidic tubing
Delivery System
Variable speed pressure or flow-controlled liquid delivery system
Tip Type
Removable tip
Flow Type
Continuous flow or static liquid
EELS/EDS Compatible
Yes
Instrument Type
TEM

Available For:

Observe dynamic liquid-phase processes in real time with controlled microfluidic flow, nanometer resolution TEM/STEM imaging, integrated MEMS heating and biasing, and optional dual-inlet solution mixing

Key Features and Capabilities

Biologic SP-200 Potentiostat

Optional add on
Expand the capabilities of the TEM Liquid Flow Sample Holder with the BioLogic SP-200 potentiostat for quantitative in-situ TEM electrochemistry

Dual-Flow Liquid Mixing

Optional add on
Accelerate discovery with dual-flow liquid mixing for in-situ liquid phase TEM, capturing dynamic liquid-liquid reactions with greater control and flexibility

Integrated Liquid Heating

Optional add on
Add temperature-controlled liquid-phase TEM capabilities with homogeneous heating, precise temperature regulation, and near-drift-free in-situ imaging

60+ In-Stock Liquid-Cell TEM Chip Configurations

Keep experiments moving with in-stock liquid-cell TEM chips designed for electrochemistry, liquid flow, heating, and multimodal microscopy workflows

TEM Safety & Seal Verification

Protect your TEM during liquid-cell experiments and streamline setup with rapid high-vacuum seal checking and optical inspection

Optimized for EELS and EDS

Perform correlative spectroscopy and microscopy for detailed in-situ elemental analysis

Multimodal Imaging

Correlate electrochemical, heating, and imaging data across TEM, SEM, and X-ray microscopy platforms

Removable, Swappable Tip and Tubing

Simplify cleaning with removable and upgradeable holder tips that allow user access for full tubing replacement

Reproducible Screw-Free Liquid-Cell Assembly

Achieve reproducible liquid-cell assembly with self-aligning windows and a screw-free sealing design

Flexible Liquid Cell Operation

Image samples in continuous-flow or static liquid environments using a sealed microfluidic chip assembly

How it works

The TEM Liquid Flow Sample Holder uses an enclosed microfluidic liquid cell to maintain a controlled liquid environment inside the high vacuum of the TEM. The liquid cell is formed by two silicon microchips with electron-transparent silicon nitride (SiN) windows that encapsulate a thin liquid layer while allowing the electron beam to pass through for nanoscale TEM and STEM imaging.

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A precision-engineered, screw-free chip loading and compression-sealing mechanism ensures reproducible liquid cell assembly and self-alignment of the imaging windows, resulting in highly reproducible experiments. The holder is also compatible with specialized microfabricated chips for MEMS heating, electrical biasing, and liquid electrochemistry, enabling multiple in-situ techniques on the same liquid flow platform.

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Liquid is delivered to the holder tip through replaceable flexible microfluidic tubing. The standard configuration supports both static and continuous liquid flow, while an optional dual-inlet configuration enables two independent solutions to mix immediately before the imaging region. Continuous flow refreshes the liquid environment during the experiment, enabling reagent exchange, removal of reaction by-products, and real-time observation of dynamic liquid-phase processes.

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Image: a) TEM Liquid Flow Sample Holder, b) Liquid holder stand, c) Microfluidics syringe pump, d) High-vacuum pump, e) Seal checking station with integrated microscope, f) Liquid holder accessory kit, g) Optional thin film liquid heating controller.