X-ray Liquid Flow Brochure | Hummingbird Scientific

Capture dynamic liquid-phase nanoscale processes with in-situ X-ray microscopy and spectroscopy. Supports static or continuous liquid flow, optional dual-inlet mixing, and MEMS heating, electrical biasing, and electrochemistry.

Technical Specs

1400 series X-ray

Number of Inlets

1 or 2 depending on model, single outlet

Biasing Contacts

4 on-chip

Tubing Type

User-replaceable microfluidic tubing

Delivery System

Variable speed pressure or flow-controlled liquid delivery system

Tip Type

Removable tip

Flow Type

Continuous flow or static liquid

Beamline Compatibility

Custom integration possible for all endstation chambers, optimized for high-resolution XAS, STXM, and ptychography beamlines where high vacuum chambers are required

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Key Features and Capabilities

Reproducible Screw-Free Liquid-Cell Assembly

Achieve reproducible liquid-cell assembly with self-aligning windows and a screw-free sealing design

Removable, Swappable Tip and Tubing

Simplify cleaning with removable and upgradeable holder tips that allow user access for full tubing replacement

Flexible Liquid Cell Operation

Analyze samples in continuous-flow or static liquid environments using a sealed microfluidic chip assembly

Multimodal Imaging

Correlate electrochemical, heating, and imaging data across TEM, SEM, and X-ray microscopy platforms

Custom X-ray Microscope Integration

Configure the holder for seamless integration with synchrotron beamlines and laboratory X-ray microscopy systems

Integrated Liquid Heating

Optional add on

Add temperature control to your in-situ liquid-phase X-ray synchrotron experiments with homogeneous heating, precise temperature regulation, and drift-free analysis

Dual-Flow Liquid Mixing

Optional add on

Accelerate discovery with dual-flow liquid mixing for in-situ liquid phase X-ray synchrotron techniques, capturing dynamic liquid-liquid reactions with greater control and flexibility

Biologic SP-200 Potentiostat

Optional add on

Expand the capabilities of the X-ray Liquid Flow Sample Holder with the BioLogic SP-200 potentiostat for quantitative in-situ X-ray electrochemistry

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Built for Diverse Applications

Magnetic polarization of nanocrystals within bacterial cells

Bio/Soft Materials

Visualize biological and soft matter systems dynamics, including growth, interactions, and degradation.

Biomineralization

Self-Assembly Processes

Metal-Organic Framework Dynamics

Soft Matter Dynamics

Biomolecular Interactions

Illustration of battery material particles and spectroscopy

Battery Materials

Directly visualize battery cycling, ion transport, dendrite formation, interface evolution, and structural changes.

Charge-Discharge Cycling

Electrochemistry

Study electrodeposition, electrocatalysis, corrosion mechanisms, and electrochemical interface evolution.

Cyclic Voltammetry (CV)

Linear Sweep Voltammetry (LSV)

Chronoamperometry (CA)

Chronopotentiometry (CP)

Electrochemical Impedance (EIS)

Featured Research

Chemical mapping of LiFePO₄ cathode nanoparticles during in-situ heating by soft X-ray spectromicroscopy

Conventional (a) and (b) and ptychographic (c) and (d) spectromicroscopy of Li_xFePO₄ microplatelets. Point spectra from conventional scanning (dashed lines) and ptychographic modes(dotted lines with circles) are shown in (e). f-g) Heating experiment showing the redistribution of chemical components when the sample is heated from f) room temperature to g) 300°C.

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Reference: David A. Shapiro, et al. Science Advances (2020). DOI: 10.1126/sciadv.abc4904

www.hummingbirdscientific.com ©Hummingbird Scientific 2026 -The specifications provided are subject to change without notice.

Selected Publications

Danwon Lee, Chihyun Nam, Juwon Kim, Sooseong Hwang, Bonho Koo, Hyejeong Hyun, Jinkyu Chung, Sungjae Seo, Munsoo Song, Jaejung Song, Myeongjun Kim, Daan Hein Alsem, Norman J. Salmon, Suyong Lee, Yeonchoo Cho, Namdong Kim, David A. Shapiro, Jongwoo Lim. “Strain-associated nanoscale fluctuating lithium transport within single-crystalline LiNi1/3Mn1/3Co1/3O2 cathode particles”. Nature Communications (2025)

DOI:

10.1038/s41467-025-64068-9

Calvin Parkin, Tyler Mefford, Jongwoo Lim, Aram Yoon, Rui Serra-Maia, Pawan Kumar, See Wee Chee, William C. Chueh, Daan Hein Alsem, Norman Salmon, Eric A. Stach. “In-Situ Liquid-Electrochemical X-Ray and Electron Microscopy for Multi-Modal Energy Materials Characterization”. ECS Meeting Abstracts (2024)

DOI:

10.1149/MA2024-01462591mtgabs

David A. Shapiro, Sergey Babin, Richard S. Celestre, Weilun Chao, Raymond P. Conley, Peter Denes, Bjoern Enders, Pablo Enfedaque, Susan James, John M. Joseph, Harinarayan Krishnan, Stefano Marchesini, Krishna Muriki, Kasra Nowrouzi, Sharon R. Oh, Howard Padmore, Tony Warwick, Lee Yang, Valeriy V. Yashchuk, Young-Sang Yu, Jiangtao Zhao. “An ultrahigh-resolution soft x-ray microscope for quantitative analysis of chemically heterogeneous nanomaterials”. Science Advances (2020)

DOI:

10.1126/sciadv.abc4904

Xiaoyang Liu, Donald Vonk, Hua Jiang, Kim Kisslinger, Xiao Tong, Mingyuan Ge, Evgeny Nazaretski, Bruce Ravel, Kate Foster, Stanislas Petrash, Yu-chen Karen Chen-Wiegart. “Environmentally Friendly Zr-Based Conversion Nanocoatings for Corrosion Inhibition of Metal Surfaces Evaluated by Multimodal X-ray Analysis”. ACS Applied Nano Materials (2019)

DOI:

10.1021/acsanm.8b02309

Tyler Mefford, Khim Karki, Daan Hein Alsem, David Shapiro, Norman Salmon, William C. Chueh. “Operando Scanning Transmission X-ray Microscopy of Co(OH)2 Oxygen Evolution Electrocatalysts”. Microscopy and Microanalysis (2019)

DOI:

10.1017/S1431927619011206